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Network motifs: structure does not determine function.

Authors
Type
Published Article
Journal
BMC Genomics
1471-2164
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
7
Pages
108–108
Identifiers
PMID: 16677373
Source
Medline

Abstract

Even with this relatively simple model, the bi-fan motif can exhibit a wide range of dynamical responses. This suggests that it is difficult to gain significant insights into biological function simply by considering the connection architecture of a gene network, or its decomposition into simple structural motifs. It is necessary to supplement such structural information by kinetic parameters, or dynamic time series experimental data, both of which are currently difficult to obtain.

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