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Network motifs: structure does not determine function.

Authors
  • Ingram, Piers J
  • Stumpf, Michael P H
  • Stark, Jaroslav
Type
Published Article
Journal
BMC Genomics
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2006
Volume
7
Pages
108–108
Identifiers
PMID: 16677373
Source
Medline
License
Unknown

Abstract

Even with this relatively simple model, the bi-fan motif can exhibit a wide range of dynamical responses. This suggests that it is difficult to gain significant insights into biological function simply by considering the connection architecture of a gene network, or its decomposition into simple structural motifs. It is necessary to supplement such structural information by kinetic parameters, or dynamic time series experimental data, both of which are currently difficult to obtain.

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