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Network Biology Empowering Detection and Understanding of Interactions Between Genetic Factors in Development of Complex Phenotypes

Authors
  • Tegnér, Jesper
  • Marabita, Francesco
  • Gomez-Cabrero, David
Type
Book
Journal
Between the Lines of Genetic Code
Publication Date
Jan 01, 2014
Pages
175–194
Identifiers
DOI: 10.1016/B978-0-12-397017-6.00010-6
ISBN: 978-0-12-397017-6
Source
Elsevier
Keywords
License
Unknown

Abstract

Following the success of genome-wide association studies, it is now important to unravel interactions between genes as well as between genes and environment. Here we discuss how to interpret higher order statistical interactions in terms of underlying biological processes purportedly generating such dependencies. In this chapter, we specifically review how biological networks, such as those generated from systems biological approaches, could possibly facilitate the interpretation of observed interactions in the development of complex phenotypes, e.g., complex diseases. We conclude that the statistical challenge is essentially a high-dimensional feature selection problem and there is therefore a need to construct intelligent priors using biological networks as a tool for the discovery and interpretation of interactions.

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