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Network analysis of auditory hallucinations in nonpsychotic individuals.

Authors
  • van Lutterveld, Remko1
  • Diederen, Kelly M J
  • Otte, Willem M
  • Sommer, Iris E
  • 1 Department of Psychiatry, University Medical Center, Utrecht, the Netherlands and Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands. , (Netherlands)
Type
Published Article
Journal
Human Brain Mapping
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 01, 2014
Volume
35
Issue
4
Pages
1436–1445
Identifiers
DOI: 10.1002/hbm.22264
PMID: 23426796
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Auditory verbal hallucinations (AVH) are a cardinal feature of schizophrenia and can severely disrupt behavior and decrease quality of life. Identification of areas with high functional connectivity (so-called hub regions) that are associated with the predisposition to hallucinate may provide potential targets for neuromodulation in the treatment of AVH. Resting-state fMRI scans during which no hallucinations had occurred were acquired from 29 nonpsychotic individuals with AVH and 29 matched controls. These nonpsychotic individuals with AVH provide the opportunity to study AVH without several confounds associated with schizophrenia, such as antipsychotic medication use and other symptoms related to the illness. Hub regions were identified by assessing weighted connectivity strength and betweenness centrality across groups using a permutation analysis. Nonpsychotic individuals with AVH exhibited increased functioning as hub regions in the temporal cortices and the posterior cingulate/precuneus, which is an important area in the default mode network (DMN), compared to the nonhallucinating controls. In addition, the right inferior temporal gyrus, left paracentral lobule and right amygdala were less important as a hub region in the AVH group. These results suggest that the predisposition to hallucinate may be related to aberrant functioning of the DMN and the auditory cortices. Copyright © 2013 Wiley Periodicals, Inc.

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