The purpose was to investigate the effect of load and fatigue on landing forces and mechanics. Thirteen Department of State special agents first completed drop jump testing, a maximal treadmill test, and another round of drop jump testing. During drop jump testing, agents performed 3 maximal effort drop jumps from 30 cm with body mass only (unloaded) or a 15 kg weight-vest (loaded). A force plate was used to collect force-time data, while two laptops were placed 3 m from the force plate from frontal and sagittal planes. Two-way analyses of variance were used to analyze the effect of load and fatigue on landing forces and Landing Error Scoring System (LESS) with alpha of p < 0.05. Dropping from 30 cm with 15 kg resulted in greater landing impulse, which was driven by increases in contact time. The loaded condition also resulted in lower jump height and reactive strength indexes. After the maximal graded treadmill test there were no further changes in drop jump ground reaction forces or performance. However, relative aerobic capacity was related to impulse changes following the treadmill test in unloaded (R2 = 0.41; p = 0.018) and loaded conditions (R2 = 0.32; p = 0.044). External loads of 15 kg increased impulse and contact time and resultantly decreased drop jump height and reactive strength indexes. It is encouraged that training protocols be aimed to concomitantly improve aerobic capacity and lower body power. Plyometric training with progressive overloading using external loads may be helpful, but further research is warranted.