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The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps.

Authors
  • Drews, Christiane
  • Senkel, Sabine
  • Ryffel, Gerhart U
Type
Published Article
Journal
BMC Developmental Biology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2011
Volume
11
Pages
5–5
Identifiers
DOI: 10.1186/1471-213X-11-5
PMID: 21281489
Source
Medline
License
Unknown

Abstract

The early nephrogenic transcription factors play an important role in nephrogenesis, but have no pronephros induction potential upon overexpression in animal caps. They activate transcriptional cascades that partially reflect the gene activation initiated by activin A and retinoic acid. Significantly, HNF1B activates the lhx1 promoter directly, thus extending the known activin A regulation of the lhx1 gene via an activin A responsive element.

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