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Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate.

Authors
Type
Published Article
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
34
Issue
18
Pages
1725–1730
Identifiers
PMID: 6539412
Source
Medline
License
Unknown

Abstract

Prenatal exposure of rats to 0.2 mg LAAM/kg/day but not to 0.05 mg LAAM/kg/day resulted in faster hot-plate escape latencies in 6 mo old offspring. No differences in tail-flick latencies were observed at 7 mo of age in offspring exposed to either dose of LAAM prenatally. Subsequent testing of littermates at 16 mo of age revealed that the greater sensitivity to the hot-plate observed in rats prenatally exposed to LAAM is apparently a result of neonatal withdrawal rather than a primary consequence of the drug. The data are discussed in relation to possible effects of drug or withdrawal on central nervous system development.

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