Affordable Access

deepdyve-link
Publisher Website

Neonatal liver failure: aetiologies and management--state of the art.

Authors
  • Shanmugam, Naresh P
  • Bansal, Sanjay
  • Greenough, Anne
  • Verma, Anita
  • Dhawan, Anil
Type
Published Article
Journal
European Journal of Pediatrics
Publisher
Springer-Verlag
Publication Date
May 01, 2011
Volume
170
Issue
5
Pages
573–581
Identifiers
DOI: 10.1007/s00431-010-1309-1
PMID: 20886352
Source
Medline
License
Unknown

Abstract

Acute liver failure in neonates is rare, but carries a high mortality. Neonatal liver failure can be defined as "failure of the synthetic function of liver within 4 weeks of birth". Encephalopathy is not essential for the diagnosis. Acute liver failure in neonates differs from children with regard to aetiology and outcome. Common causes of neonatal liver failure are neonatal hemochromatosis, haematological malignancies, viral infections and liver-based metabolic defects. Early diagnosis and referral to a paediatric liver centre is recommended as liver transplantation is the only definitive treatment when supportive or a disease-specific treatment fails.

Report this publication

Statistics

Seen <100 times