Affordable Access

deepdyve-link
Publisher Website

Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain.

Authors
  • Kakiuchi, Satsuki
  • Nonoyama, Shigeaki
  • Wakamatsu, Hajime
  • Kogawa, Kazuhiro
  • Wang, Lixin
  • Kinoshita-Yamaguchi, Hitomi
  • Takayama-Ito, Mutsuyo
  • Lim, Chang-Kweng
  • Inoue, Naoki
  • Mizuguchi, Masashi
  • Igarashi, Takashi
  • Saijo, Masayuki
Type
Published Article
Journal
Journal of Clinical Microbiology
Publisher
American Society for Microbiology
Publication Date
Jan 01, 2013
Volume
51
Issue
1
Pages
356–359
Identifiers
DOI: 10.1128/JCM.02247-12
PMID: 23100343
Source
Medline
License
Unknown

Abstract

A neonate with herpes simplex virus 1 encephalitis was treated with intravenous acyclovir. During the course of therapy, the infection became intractable to the treatment and a mutation in the viral thymidine kinase gene (nucleotide G375T, amino acid Q125H) developed. This mutation was demonstrated in vitro to confer acyclovir resistance.

Report this publication

Statistics

Seen <100 times