Affordable Access

Access to the full text

Neonatal abstinence syndrome is a potential cause of low TREC copy number

Authors
  • Adatia, Adil1
  • Ling, Ling2
  • Chakraborty, Pranesh3, 4
  • Brick, Lauren1
  • Brager, Rae1
  • 1 McMaster University, Hamilton, ON, Canada , Hamilton (Canada)
  • 2 University of Alberta, Edmonton, AB, Canada , Edmonton (Canada)
  • 3 Newborn Screening Ontario, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada , Ottawa (Canada)
  • 4 Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada , Ottawa (Canada)
Type
Published Article
Journal
Allergy, Asthma & Clinical Immunology
Publisher
BioMed Central
Publication Date
Nov 02, 2021
Volume
17
Issue
1
Identifiers
DOI: 10.1186/s13223-021-00617-3
Source
Springer Nature
Keywords
Disciplines
  • Letter to the Editor
License
Green

Abstract

Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor excision circles (TRECs) to screen for SCID in newborns, but false positives may be seen in several conditions. We report 3 newborns with neonatal abstinence syndrome who presented with decreased TREC copy number.

Report this publication

Statistics

Seen <100 times