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Neolinulicin A and B from Inula japonica and their anti-inflammatory activities.

Authors
  • Wu, Rui-Fang1
  • Zhou, Bing-Duo2
  • Wang, Wen-Qiong3
  • Chen, Tong3
  • Xu, Ting-Ting2
  • Zhu, Sheng-Liang2
  • Xuan, Li-Jiang4
  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, People's Republic of China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China. , (China)
  • 2 Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, People's Republic of China. , (China)
  • 3 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, People's Republic of China. , (China)
  • 4 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, People's Republic of China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Fitoterapia
Publication Date
Jul 01, 2021
Volume
152
Pages
104905–104905
Identifiers
DOI: 10.1016/j.fitote.2021.104905
PMID: 33848587
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A phytochemical study performed on Inula japonica led to isolation of a new 1,10-seco-sesquiterpene dimer Neolinulicin A (1) and 1,10-seco-sesquiterpene Neolinulicin B (2), together with nine known sesquiterpenes (3-11). Among them, Neolinulicin A (1), which has a new carbon skeleton, was a Diels-Alder [4 + 2] adduct of two sesquiterpene moieties. Their structures were established by extensive spectroscopic analysis. All of the isolated compounds showed inhibition of NO production in RAW 264.7 macrophages. The findings might supply information for the future design of anti-inflammatory agents from I. japonica. Copyright © 2021 Elsevier B.V. All rights reserved.

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