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Neo-clerodane diterpenoids from Conyza pyrrhopappa Sch.Bip. ex A.Rich.

Authors
  • Bitchagno, Gabin Thierry M1, 2
  • Schüffler, Anja3
  • Simo, Ingrid K1
  • Krumb, Matthias2
  • Tane, Pierre1
  • Opatz, Till2
  • 1 Department of Chemistry, University of Dschang, Dschang, Cameroon. , (Cameroon)
  • 2 Institute of Organic Chemistry, Johannes Gutenberg-University of Mainz, Mainz, Germany. , (Germany)
  • 3 Institut für Biotechnologie und Wirkstoff-Forschung gGmbH (IBWF), Kaiserslautern, Germany. , (Germany)
Type
Published Article
Journal
Natural product research
Publication Date
Oct 01, 2021
Volume
35
Issue
19
Pages
3210–3219
Identifiers
DOI: 10.1080/14786419.2019.1690490
PMID: 31726857
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Two hitherto unknown neo-clerodane-type diterpenoids along with twelve known compounds have been isolated from Conyza pyrrhopappa Sch.Bip. ex A.Rich, a medicinal plant traditionally used across tropical Africa to relieve fever. The structures of isolates have been elucidated by a combination of spectroscopic techniques. The crude extract and the isolated compounds were evaluated in the Hela-S3 cell line and in a panel of microorganisms (bacteria and fungi) at concentrations up to 50 µg/mL. The new compounds were inactive while the pentamethylated flavonoids showed low to significant activity against the cancer cell line used. However, none of the samples showed any activity against the tested microorganisms at this concentration. The present manuscript is the first investigation of the cytotoxicity of phytochemicals and extract from C. pyrrhopappa.

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