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[Neoangiogenesis: from molecular biology to clinical medicine].

Authors
  • Odoni, G
  • Amann, K
  • Ritz, E
Type
Published Article
Journal
Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Publication Date
Jan 01, 2003
Volume
20
Issue
6
Pages
573–577
Identifiers
PMID: 14732908
Source
Medline
License
Unknown

Abstract

Cardiovascular disease is the most common cause of premature death in patients with end-stage renal disease, probably due to a specific "uraemic cardiomyopathy" This article reviews the pathogenesis of cardiac changes in uraemia and particularly the role of an impaired vessel formation. Experimental and autoptic data showed remarkable changes in heart capillarization in renal failure, i.e. a decrease in myocardial capillary supply and a concomitant increase in intercapillary distance. Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis), such as VEGF, constitutes a promising approach for the treatment of uraemic cardiomyopathy.

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