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Neoadjuvant therapy for esophageal cancer: surgical considerations.

Authors
  • Piraino, Alessio
  • Vita, Maria Letizia
  • Tessitore, Adele
  • Cusumano, Giacomo
  • Congedo, Maria Teresa
  • Margaritora, Stefano
  • Porziella, Venanzio
  • Meacci, Elisa
  • Cesario, Alfredo
  • Granone, Pierluigi
Type
Published Article
Journal
Rays
Publication Date
Jan 01, 2006
Volume
31
Issue
1
Pages
37–45
Identifiers
PMID: 16999374
Source
Medline
License
Unknown

Abstract

Esophageal carcinoma is often diagnosed at an advanced, non resectable stage. Only early stages show a better prognosis. Surgical treatment represents the gold standard. The various surgical techniques do not seem to affect survival. Based on the severity of esophageal cancer and on poor outcome achievable with surgery alone, multimodality treatments are the most suitable. The possible negative impact on the complication rate after neoadjuvant therapy is still debated. Most randomized trials have not demonstrated as yet an improvement in prognosis in patients undergoing a three-modality treatment. However, patients with complete pathologic response after surgical resection were shown to have a better prognosis. In conclusion, additional randomized trials are required, aimed at evaluating all technical and therapeutic variables which affect prognosis.

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