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Negligible effect of tenofovir on atazanavir trough concentrations and genotypic inhibitory quotients in the presence and absence of ritonavir.

Authors
  • Fournier, Cassandra
  • Higgins, Niamh
  • Thomas, Réjean
  • Baril, Jean-Guy
  • Thibeault, Denis
  • Lalonde, Richard
  • Sheehan, Nancy L
Type
Published Article
Journal
Therapeutic Drug Monitoring
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Apr 01, 2013
Volume
35
Issue
2
Pages
264–269
Identifiers
DOI: 10.1097/FTD.0b013e3182834057
PMID: 23503454
Source
Medline
License
Unknown

Abstract

In patients receiving TDF, ritonavir increased the ATV C trough and GIQ and patients on ATV/r were more likely to have therapeutic C troughs. However, among subjects without ritonavir boosting, TDF compared with other nucleosides did not influence the odds of achieving a therapeutic ATV C trough. These data suggest that ritonavir boosting of ATV is prudent, particularly in patients with resistance mutations.

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