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Necessity of rethinking oral pediatric formulations.

Authors
  • Bar-Shalom, Daniel1
  • 1 Department of Pharmacy, School of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark; and Bioneer A/S, Hørsholm, Denmark. Electronic address: [email protected] , (Denmark)
Type
Published Article
Journal
Clinical therapeutics
Publication Date
Feb 01, 2014
Volume
36
Issue
2
Pages
180–183
Identifiers
DOI: 10.1016/j.clinthera.2014.01.010
PMID: 24529290
Source
Medline
License
Unknown

Abstract

This commentary reviews the difficulties in formulating oral products for children. The significance of the fragmentation of the pediatric population in terms of development and ability to ingest different dosage formulations is examined. It is postulated that a flexible formulation, acceptable by all patient groups, is needed, and an automated compounding concept is proposed. The finishing of the formulation is done at the dispensing pharmacy using an automated process. The individual components (pudding-like carrier, microencapsulated drug, and the dispensing robot and its software) are reviewed. The involvement of different stakeholders is considered because new regulatory, clinical, and marketing thinking is required.

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