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Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe3O4 carbon dots with graphitic black phosphorus quantum dots.

Authors
  • Zhang, Ming1, 2
  • Wang, Wentao3
  • Cui, Yingjun2
  • Zhou, Ninglin1, 4
  • Shen, Jian1
  • 1 College of Chemistry and Materials Science, Jiangsu Collaborative Innovation Center for Biological Functional Materials, Jiangsu Engineering Research, Center for Biomedical Function Materials, Nanjing, Jiangsu, China. , (China)
  • 2 Department of Biological Sciences, Florida International University, Miami, FL, USA.
  • 3 Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China. , (China)
  • 4 Faculty of Materials Development, Nanjing Zhou Ninglin Advanced Materials Technology Company Limited, Nanjing, Jiangsu, China. , (China)
Type
Published Article
Journal
International Journal of Nanomedicine
Publisher
Dove Medical Press
Publication Date
Jan 01, 2018
Volume
13
Pages
2803–2819
Identifiers
DOI: 10.2147/IJN.S156434
PMID: 29785107
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Recently, combined photodynamic therapy (PDT) and photothermal therapy (PTT) has become a desired treatment for cancer. However, the development of economic, high-efficiency, and safe photosensitizers/photothermal agents remains a significant challenge. A novel nanocomposite has been developed via the assembly of iron oxide carbon dot (Fe3O4-CDs) nanoparticles and black phosphorus quantum dots (genipin [GP]-polyglutamic acid [PGA][email protected]), and this nanocomposite shows a broad light-absorption band and a photodegradable character. In vitro and in vivo assays indicated that [email protected] were highly biocompatible and exhibited excellent tumor-inhibition efficacy, due to the synergistic PTT and PDT via a near-infrared laser. Importantly, in vivo tumor magnetic resonance imaging (MRI) results illustrated that [email protected] can be specifically applied for enhanced T2 MRI of tumors. This work presents the first combined application of a PDT and PTT effect deriving from BPQDs and MRI from Fe3O4-CDs, which may promote utilization of black BPQDs in biomedicine. As expected, [email protected] displayed a dramatically enhanced ability to destroy tumor cells, due to the synergistic combination of PTT and PDT.

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