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Near-infrared light-responsive intracellular drug and siRNA release using au nanoensembles with oligonucleotide-capped silica shell.

Authors
  • Chang, Yi-Ting
  • Liao, Pei-Yi
  • Sheu, Hwo-Shuenn
  • Tseng, Yu-Jui
  • Cheng, Fong-Yu
  • Yeh, Chen-Sheng
Type
Published Article
Journal
Advanced Materials
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jul 03, 2012
Volume
24
Issue
25
Pages
3309–3314
Identifiers
DOI: 10.1002/adma.201200785
PMID: 22648937
Source
Medline
License
Unknown

Abstract

Taking advantage of the character of Au nanorods (NRs) to absorb NIR light, a NIR-responsive oligonucleotide-gated ensemble is developed to perform intracellular drug delivery. Using an oligonucleotide bio-gate enables siRNA release into cells for translational regulation as well as cytotoxicity in anti-cancer drug delivery.

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