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ncRI: a manually curated database for experimentally validated non-coding RNAs in inflammation

Authors
  • Wang, Shuyuan1
  • Zhou, Shunheng2
  • Liu, Haizhou2
  • Meng, Qianqian1
  • Ma, Xueyan1
  • Liu, Hui1
  • Wang, Lihong3
  • Jiang, Wei1, 2
  • 1 Harbin Medical University, Harbin, 150081, China , Harbin (China)
  • 2 Nanjing University of Aeronautics and Astronautics, Nanjing, 211106, China , Nanjing (China)
  • 3 Southeast University, Nanjing, 210009, China , Nanjing (China)
Type
Published Article
Journal
BMC Genomics
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jun 01, 2020
Volume
21
Issue
1
Identifiers
DOI: 10.1186/s12864-020-06794-6
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundInflammation has been considered to be central to the onset, progression, and outcome of infectious diseases, especially as one of the hallmarks of cancer. Non-coding RNAs (ncRNAs), such as miRNAs and lncRNAs, have emerged as vital regulators in control of immune and inflammatory processes, and also play important roles in the inflammatory disease and immunotherapy.ResultsIn this study, we presented a database ncRI, which documented experimentally verified ncRNAs in inflammatory diseases, from published articles. Each entry contained the detailed information about ncRNA name, inflammatory diseases, mechanism, experimental techniques (e.g., microarray, RNA-seq, qRT-PCR), experimental samples (cell line and/or tissue), expression patterns of ncRNA (up-regulated or down-regulated), reference information (PubMed ID, year of publication, title of paper) and so on. Collectively, ncRI recorded 11,166 entries that include 1976 miRNAs, 1377 lncRNAs and 107 other ncRNAs across 3 species (human, mouse, and rat) from more than 2000 articles. All these data are free for users to search, browse and download.ConclusionIn summary, the presented database ncRI provides a relatively comprehensive credible repository about ncRNAs and their roles in inflammatory diseases, and will be helpful for research on immunotherapy. The ncRI is now freely available to all users at http://www.jianglab.cn/ncRI/.

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