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NCAM (CD56)-positive malignant lymphoma.

Authors
  • Kern, W F
  • Spier, C M
  • Miller, T P
  • Grogan, T M
Type
Published Article
Journal
Leukemia & lymphoma
Publication Date
Dec 01, 1993
Volume
12
Issue
1-2
Pages
1–10
Identifiers
PMID: 7512851
Source
Medline
License
Unknown

Abstract

CD56 has been found to identify an isoform of the neural cell adhesion (NCAM). NCAM is a member of the immunoglobulin superfamily of cell adhesion molecules; it is related to a variety of leukocyte antigens and to several cell adhesion molecules believed relevant to malignant behavior in a variety of neoplasms. It contains polysialic acid, which appears to regulate binding avidity of NCAM and other cell adhesion processes. We have identified a group of NCAM-positive lymphomas. Compared to a group of NCAM-negative lymphomas, this group exhibited frequent involvement of unusual sites and a generally aggressive course. Another series of CD56-positive hematolymphoid malignancies has recently been described, from Hong Kong; this group also exhibited involvement of unusual sites and displayed a very aggressive course. Together these series suggest that NCAM on lymphoma is of biological and clinical significance in terms of tumor behavior and spread.

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