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Genome Wide MeDIP-Seq Profiling of Wild and Cultivated Olives Trees Suggests DNA Methylation Fingerprint on the Sensory Quality of Olive Oil.

Authors
  • Badad, Oussama1, 2
  • Lakhssassi, Naoufal1
  • Zaid, Nabil2
  • El Baze, Abdelhalim1
  • Zaid, Younes2, 3
  • Meksem, Jonas4
  • Lightfoot, David A1
  • Tombuloglu, Huseyin5
  • Zaid, El Houcine2
  • Unver, Turgay6
  • Meksem, Khalid1
  • 1 Department of Plant, Soil and Agricultural Systems, Southern Illinois University, Carbondale, IL 62901, USA.
  • 2 Department of Biology, Faculty of Sciences, Mohammed V University, Rabat 10000, Morocco. , (Morocco)
  • 3 Research Center, Abulcasis University of Health Sciences, Rabat 10000, Morocco. , (Morocco)
  • 4 Trinity College of Arts and Sciences, Duke University, Durham, NC 27708, USA.
  • 5 Department of Genetics Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia. , (Saudi Arabia)
  • 6 Ficus Biotechnology, Ostim OSB Mah, 100. Yil Blv, No:55, Yenimahalle, Ankara 06000, Turkey. , (Turkey)
Type
Published Article
Journal
Plants
Publisher
MDPI AG
Publication Date
Jul 09, 2021
Volume
10
Issue
7
Identifiers
DOI: 10.3390/plants10071405
PMID: 34371608
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Secondary metabolites are particularly important to humans due to their pharmaceutical properties. Moreover, secondary metabolites are key compounds in climate change adaptation in long-living trees. Recently, it has been described that the domestication of Olea subspecies had no major selection signature on coding variants and was mainly related to changes in gene expression. In addition, the phenotypic plasticity in Olea subspecies was linked to the activation of transposable elements in the genes neighboring. Here, we investigated the imprint of DNA methylation in the unassigned fraction of the phenotypic plasticity of the Olea subspecies, using methylated DNA immuno-precipitation sequencing (MeDIP-seq) for a high-resolution genome-wide DNA methylation profiling of leaves and fruits during fruit development in wild and cultivated olives from Turkey. Notably, the methylation profiling showed a differential DNA methylation in secondary metabolism responsible for the sensory quality of olive oil. Here, we highlight for the first time the imprint of DNA methylation in modulating the activity of the Linoleate 9S lipoxygenase in the biosynthesis of volatile aromatic compounds. Unprecedently, the current study reveals the methylation status of the olive genome during fruit ripening.

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