The ongoing activity of the ganglionic cells innervating the normal and partial denervated submandibular gland of rat was investigated with intracellular recording. With the aim to be identified these cells were preliminary labeled by the fluorescent dye Di-1. The most of neurons innervating the normal gland were entirely silent. Ongoing activity was found only in 11% of these neurons and the average frequency of discharge was 0.1 +/- 0.01/s. After partial denervation of the gland, the number of active ganglion cells among the neurons innervating the gland increased from 11 to 42%. The average frequency of discharge in these cells has increased about three times. The data suggest that changes found in neurons innervating the partially denervated gland were a result of the increase in convergence of preganglionic fibres on these neurons.