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Natural occurence of a biopolymer, poly (adenosine diphosphate ribose).

Authors
  • Sakura, H
  • Miwa, M
  • Tanaka, M
  • Kanai, Y
  • Shimada, T
  • Matsushima, T
  • Sugimura, T
Type
Published Article
Journal
Nucleic acids research
Publication Date
Aug 01, 1977
Volume
4
Issue
8
Pages
2903–2915
Identifiers
PMID: 198744
Source
Medline
License
Unknown

Abstract

Evidence for the natural occurrence of poly(adenosine diphosphate ribose) in vivo was obtained using a sensitive radioimmunoassay and poly(adenosine diphosphate ribose) glycohydrolase, which specifically hydrolyzes poly(adenosine diphosphate ribose). Calf thymus, liver, kidney, brain, pancreas and spleen contained poly(adenosine diphosphate ribose). Naturally occurring poly(adenosine diphosphate ribose) in calf thymus is composed of molecules of various chain lengths, like that synthesized by an in vitro system. Calf thymus was estimated to contain about 0.02 microgram/mg DNA of poly(adenosine diphosphate ribose).

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