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Natural history of symptomatic intracranial arterial stenosis.

Authors
  • Kasner, Scott E1
  • 1 Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA. [email protected]
Type
Published Article
Journal
Journal of Neuroimaging
Publisher
Wiley (Blackwell Publishing)
Publication Date
Oct 01, 2009
Volume
19 Suppl 1
Identifiers
DOI: 10.1111/j.1552-6569.2009.00417.x
PMID: 19807853
Source
Medline
License
Unknown

Abstract

Patients who have had a stroke or transitory ischemic attack (TIA) attributed to stenosis (50-99%) of a major intracranial artery face a 12-14% risk of subsequent stroke during the 2-year period after the initial ischemic event, despite treatment with antithrombotic medications. Most of this risk accrues during the first year. Some patients are at substantially greater risk, particularly those with a severe (70-99%) stenosis, those who have recently had an ischemic event, and women. Patients may also be at high risk if they had an initial stroke rather than TIA or if they have symptoms precipitated by hemodynamic maneuvers. The annual risk of subsequent stroke may exceed 20% in these high-risk groups.

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