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The natural history of early versus late disability accumulation in primary progressive MS.

Authors
  • Koch, Marcus W
  • Greenfield, Jamie
  • Javizian, Omid
  • Deighton, Stephanie
  • Wall, Winona
  • Metz, Luanne M
Type
Published Article
Journal
Journal of Neurology Neurosurgery & Psychiatry
Publisher
BMJ
Publication Date
Jun 01, 2015
Volume
86
Issue
6
Pages
615–621
Identifiers
DOI: 10.1136/jnnp-2014-307948
PMID: 25091366
Source
Medline
Keywords
License
Unknown

Abstract

Age at disease onset is the most important predictor of disability accumulation in PPMS. Bilateral motor onset symptoms were associated with quicker disease progression. In contrast to RRMS, we found no evidence for distinct phases of disability accumulation in PPMS. Disability accumulation in PPMS appears to be affected by the same factors throughout its course.

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