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Natural history of acromegalic peripheral neuropathy.

Authors
  • Dinn, J J
  • Dinn, E I
Type
Published Article
Journal
The Quarterly journal of medicine
Publication Date
Dec 01, 1985
Volume
57
Issue
224
Pages
833–842
Identifiers
PMID: 3006115
Source
Medline
License
Unknown

Abstract

Eleven sural nerve biopsies from nine acromegalic patients, with and without peripheral neuropathy, were examined utilizing routine sections, single teased fibres and electron microscopy. The initial basic pathological lesion in both groups consisted of demyelination combined with hypertrophic formations affecting the Schwann cell system of the small diameter fibres. Second biopsies from two patients with neuropathy demonstrate the natural history of the lesion. The progression to eventual end-stage neuropathy is documented and is due to the marked onion bulb formation. Recovery is unlikely. Our findings indicate that the development of peripheral neuropathy in acromegaly is a serious complication. Deterioration, both clinically and pathologically, can be expected if the growth hormone remains persistently elevated.

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