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A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011–2015 update

Authors
  • Tateishi, Ryosuke1
  • Uchino, Koji1
  • Fujiwara, Naoto1
  • Takehara, Tetsuo2
  • Okanoue, Takeshi3
  • Seike, Masataka4
  • Yoshiji, Hitoshi5
  • Yatsuhashi, Hiroshi6
  • Shimizu, Masahito7
  • Torimura, Takuji8
  • Moriyama, Mitsuhiko9
  • Sakaida, Isao10
  • Okada, Hiroyuki11
  • Chiba, Tetsuhiro12
  • Chuma, Makoto13
  • Nakao, Kazuhiko14
  • Isomoto, Hajime15
  • Sasaki, Yutaka16
  • Kaneko, Shuichi17
  • Masaki, Tsutomu18
  • And 2 more
  • 1 The University of Tokyo, Department of Gastroenterology, Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan , Tokyo (Japan)
  • 2 Osaka University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Suita, Japan , Suita (Japan)
  • 3 Saiseikai Suita Hospital, Department of Gastroenterology and Hepatology, Suita, Japan , Suita (Japan)
  • 4 Oita University, Depatment of Gastroenterology, Faculty of Medicine, Yufu, Japan , Yufu (Japan)
  • 5 Nara Medical University, Third Department of Internal Medicine, Kashihara, Japan , Kashihara (Japan)
  • 6 Nagasaki University Graduate School of Biomedical Sciences, Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Nagasaki, Japan , Nagasaki (Japan)
  • 7 Gifu University Graduate School of Medicine, Department of Gastroenterology, Gifu, Japan , Gifu (Japan)
  • 8 Kurume University School of Medicine, Division of Gastroenterology, Department of Internal Medicine, Kurume, Japan , Kurume (Japan)
  • 9 Nihon University School of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokyo, Japan , Tokyo (Japan)
  • 10 Yamaguchi University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Ube, Japan , Ube (Japan)
  • 11 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Gastroenterology and Hepatology, Okayama, Japan , Okayama (Japan)
  • 12 Chiba University, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba, Japan , Chiba (Japan)
  • 13 Yokohama City University Medical Center, Gastroenterological Center, Yokohama, Japan , Yokohama (Japan)
  • 14 Nagasaki University of Graduate School of Biomedical Sciences, Department of Gastroenterology and Hepatology, Nagasaki, Japan , Nagasaki (Japan)
  • 15 Tottori University, Faculty of Medicine, Medicine and Clinical Science, Yonago, Japan , Yonago (Japan)
  • 16 Kumamoto University, Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto, Japan , Kumamoto (Japan)
  • 17 Kanazawa University, Department of Gastroenterology, Graduate School of Medicine, Kanazawa, Japan , Kanazawa (Japan)
  • 18 Kagawa University, Department of Gastroenterology and Neurology, Faculty of Medicine, Takamatsu, Japan , Takamatsu (Japan)
  • 19 Hiroshima University, Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima, Japan , Hiroshima (Japan)
Type
Published Article
Journal
Journal of Gastroenterology
Publisher
Springer Japan
Publication Date
Nov 29, 2018
Volume
54
Issue
4
Pages
367–376
Identifiers
DOI: 10.1007/s00535-018-1532-5
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundWe previously reported that the incidence of hepatocellular carcinoma (HCC) with non-viral etiologies increased rapidly between 1991 and 2010 in Japan.MethodsTo update this investigation, we enrolled patients who were initially diagnosed as having non-B, non-C HCC at participating hospitals between 2011 and 2015. In addition to the patient characteristics investigated in the previous report, we also investigated the duration of alcohol consumption. The overall survival rate was analyzed using the Kaplan–Meier method, and the hazard function against the body mass index (BMI) was plotted using cubic splines.ResultsA total of 2087 patients were enrolled. The proportion of patients with non-viral etiologies has continued to increase from 10.0% in 1991 to 32.5% in 2015. Patients were also older (median ages, 70–73 years) and more obese (median BMIs, 23.9–24.2 kg/m2), and the proportions of patients with diabetes mellitus (46.1% to 51.6%), hypertension (42.7% to 58.6%), dyslipidemia (14.6% to 22.9%), and fatty liver (24.0% to 28.8%) had all increased significantly. There was a significant inverse relationship between the duration and the amount of daily alcohol consumption. The improvement in the overall survival was relatively small, with a decreased proportion of patients under surveillance (41.3% to 31.6%). A hazard function plot showed a curve similar to that in our previous report, with a lowest hazard of ~ 26 kg/m2.ConclusionsThe proportion of HCC patients with non-viral etiologies continues to increase in Japan. Lifetime total amount of alcohol consumption may be a risk factor.

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