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A nanoparticulate drug-delivery system for rivastigmine: physico-chemical and in vitro biological characterization.

Authors
  • Craparo, Emanuela Fabiola
  • Pitarresi, Giovanna
  • Bondì, Maria Luisa
  • Casaletto, Maria Pia
  • Licciardi, Mariano
  • Giammona, Gaetano
Type
Published Article
Journal
Macromolecular bioscience
Publication Date
Mar 10, 2008
Volume
8
Issue
3
Pages
247–259
Identifiers
PMID: 18041108
Source
Medline
License
Unknown

Abstract

The preparation and characterization of surface-PEGylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM-PEG(2000) as an inverse microemulsion, using an aqueous solution of the PHM/PHM-PEG(2000) copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta-potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug-release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.

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