Affordable Access

Nanoparticle amplification <i>via</i> photothermal unveiling of cryptic collagen binding sites.

Authors
Type
Published Article
Journal
Journal of Materials Chemistry B
Publisher
The Royal Society of Chemistry
Volume
1
Issue
39
Pages
5235–5240
Source
Ruoslahti Lab
License
Unknown

Abstract

The success of nanoparticle-based cancer therapies ultimately depends on their ability to selectively and efficiently accumulate in regions of disease. Outfitting nanoparticles to actively target tumor-specific markers has improved specificity, yet it remains a challenge to amass adequate therapy in a selective manner. To help address this challenge, we have developed a mechanism of nanoparticle amplification based on stigmergic (environment-modifying) signalling, in which a "Signalling" population of gold nanorods induces localized unveiling of cryptic collagen epitopes, which are in turn targeted by "Responding" nanoparticles bearing gelatin-binding fibronectin fragments. We demonstrate that this two-particle system results in significantly increased, selective recruitment of responding particles. Such amplification strategies have the potential to overcome limitations associated with single-particle targeting by leveraging the capacity of nanoparticles to interact with their environment to create abundant new binding motifs.

Report this publication

Statistics

Seen <100 times