Affordable Access

deepdyve-link
Publisher Website

Nanofibrous cosmetic face mask for transdermal delivery of nano gold: synthesis, characterization, release and zebra fish employed toxicity studies.

Authors
  • Manatunga, D C1
  • Godakanda, V U1
  • Herath, H M L P B1
  • de Silva, Rohini M1
  • Yeh, Chen-Yu2
  • Chen, Jiann-Yeu3
  • Akshitha de Silva, A A2
  • Rajapaksha, S4
  • Nilmini, Renuka4
  • Nalin de Silva, K M1
  • 1 Centre for Advanced Materials and Devices, Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka. , (Sri Lanka)
  • 2 Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan. , (Taiwan)
  • 3 Research Centre for Sustainable Energy and Nanotechnology (RCSEN), National Chung Hsing University, Taichung 402, Taiwan. , (Taiwan)
  • 4 Department of Engineering Technology, Faculty of Technology, University of Sri Jayawardenapura, Sri Lanka. , (Sri Lanka)
Type
Published Article
Journal
Royal Society Open Science
Publisher
The Royal Society
Publication Date
Sep 01, 2020
Volume
7
Issue
9
Pages
201266–201266
Identifiers
DOI: 10.1098/rsos.201266
PMID: 33047067
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This study involves the generation of gold nanoparticles (Au NPs) via a novel natural/non-toxic methodology using tea and orange-peel extracts. These were then embedded into a novel blend composed of a polyethylene oxide and gelatin (PEO-Gel) fibre mat. The scanning electron microscopy results indicated that the addition of both collagen (COL) and ascorbic acid (AA) into the PEO-Gel system (PEO-Gel-AA-COL system) enhances the Au NP incorporation into nanofibres leading to a diameter of 164.60 ± 20.95 and 192.43 ± 39.14 nm in contrast to the spraying observed with the Au PEO-Gel system alone. Releasing studies conducted over 30 min indicated that the PEO-Gel-AA-COL-orange peel Au (OpAu) system accounts for a higher content of Au release than the green tea Au (GtAu) NP system where a maximum release could be attained within 10-30 min depending on the amount of Au NPs that have been incorporated. Moreover, the transdermal diffusion studies conducted using Strat membrane indicated that Au NPs from both formulations (PEO-Gel-AA-COL-GtAu nanofibre, PEO-Gel-AA-COL-OpAu nanofibre) have diffused through the stratum corneum and trapped in the dermis and epidermis indicating its transdermal deliverability. Additionally, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay revealed that nanofibres have similar radical scavenging activity like AA standard. Toxicity evaluation on a zebra fish embryo model confirmed that both GtAu NPs and OpAu NPs do not induce any teratogenic activity and are safe to be used in the range of 1.0-167 µg ml-1. © 2020 The Authors.

Report this publication

Statistics

Seen <100 times