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Nano-based approach to combat emerging viral (NIPAH virus) infection

Authors
  • Kerry, Rout George1
  • Malik, Santosh2
  • Redda, Yisehak Tsegaye3
  • Sahoo, Sabuj1
  • Patra, Jayanta Kumar4
  • Majhi, Sanatan1
  • 1 ar, Odisha, India
  • 2 Departmentof Life Science, National Institute of Technology, Rourkela, Odisha, India
  • 3 College of Veterinary Medicine, Mekelle University, Ethiopia
  • 4 Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi, Republic of Korea
Type
Published Article
Journal
Nanomedicine
Publisher
Elsevier Inc.
Publication Date
Mar 21, 2019
Volume
18
Pages
196–220
Identifiers
DOI: 10.1016/j.nano.2019.03.004
PMID: 30904587
PMCID: PMC7106268
Source
PubMed Central
Keywords
License
Unknown

Abstract

Nipah virus (NiV) infects the host cell via cell surface receptor leading to the formation of syncytium, gradual degradation of which leads to the release of the virus in to blood streams, and transmission of infection to different organs. With nanotechnology it could be possible to detect and inactivate NiV infection specifically through targeted tagging or by blocking viral surface proteins. As these viral surface proteins are also expressed in NiV-infected cell which contributes towards the formation of syncytium, therefore designing a targeted nano-system against these expressed proteins, could also be helpful in prohibiting the spread of viral infection. Unlabelled Image

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