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NAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia.

Authors
  • Pereira, Daniela A1
  • Sandrim, Valéria C2
  • Palei, Ana C T3
  • Tanus-Santos, Jose E4
  • Belo, Vanessa A1
  • Cavalli, Ricardo C5
  • Luizon, Marcelo R6
  • 1 Graduate Program in Genetics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. , (Brazil)
  • 2 Department of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil. , (Brazil)
  • 3 Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
  • 4 Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil. , (Brazil)
  • 5 Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil. , (Brazil)
  • 6 Graduate Program in Genetics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. Electronic address: [email protected] , (Brazil)
Type
Published Article
Journal
Pregnancy hypertension
Publication Date
Oct 11, 2019
Volume
18
Pages
137–140
Identifiers
DOI: 10.1016/j.preghy.2019.09.022
PMID: 31610400
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

NAMPT is a biomarker for endothelial dysfunction, but its relationship with nitrite (marker of NO formation) and soluble fms-like tyrosine kinase-1 (sFLT-1) has not been previously evaluated in preeclampsia. Therefore, we measured plasma NAMPT and sFLT-1 levels using enzyme immunoassays and plasma nitrite concentrations using an ozone-based chemiluminescence assay. NAMPT was positively correlated to nitrite (r = 0.217; P = 0.034) and inversely related to sFLT-1 (r = -0.340; P = 0.029) in healthy pregnant women, but inversely related to nitrite (r = -0.259; P = 0.035) and positively correlated to sFLT-1 (r = 0.326; P = 0.007) in preeclamptic patients, suggesting that NAMPT inhibits NO formation and interacts with the antiangiogenic factor sFLT-1 in preeclampsia. Copyright © 2019 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

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