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Nabilone: a pressure-reducing synthetic benzopyran in open-angle glaucoma.

Authors
  • Newell, F W
  • Stark, P
  • Jay, W M
  • Schanzlin, D J
Type
Published Article
Journal
Ophthalmology
Publisher
Elsevier
Publication Date
Jan 01, 1979
Volume
86
Issue
1
Pages
156–160
Identifiers
PMID: 530560
Source
Medline
License
Unknown

Abstract

Nabilone is a synthesized crystalline benzopyran that resembles the cannabinols but is not a tetrahydrocannabinol. Oral administration of 0.5 to 2 mg to patients with open-angle glaucoma reduced the intraocular pressure from 10% to 54% with an average of 28%. Administration of a topical ophthalmic nabilone solution (0.1 mg/drop) to both eyes of adult albino rabbits (1.5 to 3.5 kg) lowered the IOP an average of 25%. The peak action of the nabilone administered in this manner was 60 minutes, with a return to normal IOP by 180 minutes. Tolerance developed in rabbits after one week of topical administration.

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