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Na+/H+ exchanger mediates TNF-alpha-induced hepatocyte apoptosis via the calpain-dependent degradation of Bcl-xL.

Authors
  • Liu, Zhan
  • Wang, Shuangxi
  • Zhou, Huixin
  • Yang, Yuming
  • Zhang, Mingliang
Type
Published Article
Journal
Journal of Gastroenterology and Hepatology
Publisher
Wiley (Blackwell Publishing)
Publication Date
May 01, 2009
Volume
24
Issue
5
Pages
879–885
Identifiers
DOI: 10.1111/j.1440-1746.2008.05715.x
PMID: 19220664
Source
Medline
License
Unknown

Abstract

TNF-alpha via NHE results in hepatocyte apoptosis through the calcium/calpain/Bcl-xL pathway.

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