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N-phenylethyl amitriptyline in rat sciatic nerve blockade.

Authors
  • Gerner, Peter
  • Mujtaba, Mustafa
  • Khan, Mohammed
  • Sudoh, Yukari
  • Vlassakov, Kamen
  • Anthony, Douglas C
  • Wang, Ging Kuo
Type
Published Article
Journal
Anesthesiology
Publication Date
Jun 01, 2002
Volume
96
Issue
6
Pages
1435–1442
Identifiers
PMID: 12170057
Source
Medline
License
Unknown

Abstract

N-phenylethyl amitriptyline appears to have a narrow therapeutic range but is much more potent than lidocaine, providing a block duration several times longer than any clinically used local anesthetic. Further work in animal models of neuropathic pain will assess the potential use of this drug.

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