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N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes.

Authors
  • Moazzen, Hoda
  • Lu, Xiangru
  • Ma, Noelle L
  • Velenosi, Thomas J
  • Urquhart, Brad L
  • Wisse, Lambertus J
  • Gittenberger-de Groot, Adriana C
  • Feng, Qingping
Type
Published Article
Journal
Cardiovascular Diabetology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2014
Volume
13
Pages
46–46
Identifiers
DOI: 10.1186/1475-2840-13-46
PMID: 24533448
Source
Medline
License
Unknown

Abstract

Treatment with NAC increases GSH levels, decreases ROS levels in the fetal heart and prevents the development of CHDs in the offspring of pregestational diabetes. Our study suggests that NAC may have therapeutic potential in the prevention of CHDs induced by pregestational diabetes.

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