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N-acetylcysteine attenuates cyclosporin-induced nephrotoxicity in rats.

Authors
  • Tariq, M
  • Morais, C
  • Sobki, S
  • Al Sulaiman, M
  • Al Khader, A
Type
Published Article
Journal
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Publication Date
Apr 01, 1999
Volume
14
Issue
4
Pages
923–929
Identifiers
PMID: 10328471
Source
Medline
License
Unknown

Abstract

CsA-induced nephrotoxicity was significantly attenuated by NAC. This study clearly suggests the role of oxidative stress in the pathogenesis of CsA-induced nephrotoxicity. Concomitant use of antioxidants such as NAC to minimize CsA-induced nephrotoxicity in humans warrant further studies.

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