Affordable Access

deepdyve-link
Publisher Website

Myxoid variant of anaplastic large cell lymphoma involving the skin: a case report.

Authors
  • Gable, Ashley D
  • Clark, Sandra H
  • Magro, Cynthia M
Type
Published Article
Journal
Journal of Cutaneous Pathology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Aug 01, 2012
Volume
39
Issue
8
Pages
787–790
Identifiers
DOI: 10.1111/j.1600-0560.2012.01911.x
PMID: 22612158
Source
Medline
License
Unknown

Abstract

We report the case of a 62-year-old white male who presented with a 2.6-cm ulcerating mass on the skin of the left buttock and ipsilateral inguinal lymphadenopathy. Microscopic sections of the skin lesion showed a nodular and plaque-like growth pattern of a mixed cellular infiltrate throughout the dermis and subcutaneous tissue with prominent myxoid change. There was a dominant population of medium-sized mitotically active atypical cells that expressed CD30, CD4 and EMA. These atypical cells were mixed with eosinophils, neutrophils, mature lymphocytes and histiocytes. Tissue from the inguinal lymphadenopathy showed similar pathologic features, although no residual lymph node tissue was present. A diagnosis of secondary anaplastic large cell lymphoma, myxoid variant, with skin and lymph node/perinodal soft tissue involvement was rendered at the time of complete excision of the buttock mass. The patient received five cycles of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy with complete resolution of lymphadenopathy and no residual cutaneous disease. He was disease-free by PET/CT scan and physical examination at 16 months after chemotherapy. We present this case to highlight the histopathologic and immunophenotypic features of this entity with a discussion of the differential diagnosis and a review of the literature.

Report this publication

Statistics

Seen <100 times