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Myxoid hepatocellular adenoma, a rare variant of hepatocellular adenoma with distinct imaging features: A case report with immunohistochemical and molecular analysis and literature review.

Authors
  • De Vos, Nicolas1
  • Van der Meulen, Joni2
  • Van Der Linden, Malaïka3
  • Claes, Kathleen4
  • Candaele, Ann-Sophie5
  • Vanlander, Aude6
  • Troisi, Roberto Ivan7
  • Van Vlierberghe, Hans8
  • Smeets, Peter9
  • Van Dorpe, Jo10
  • Hoorens, Anne11
  • 1 Department of Radiology, Ghent University Hospital, Ghent 9000, Belgium. Electronic address: [email protected] , (Belgium)
  • 2 Centre for Medical Genetics, Ghent University Hospital, Ghent 9000, Belgium. Electronic address: [email protected] , (Belgium)
  • 3 Department of Pathology, Ghent University Hospital, Ghent 9000, Belgium. Electronic address: [email protected] , (Belgium)
  • 4 Centre for Medical Genetics, Ghent University Hospital, Ghent 9000, Belgium. Electronic address: [email protected] , (Belgium)
  • 5 Department of Pathology, Ghent University Hospital, Ghent 9000, Belgium. Electronic address: [email protected] , (Belgium)
  • 6 Department of General Hepatobiliary and Liver Transplantation Surgery, Ghent University Hospital, Ghent 9000, Belgium. Electronic address: [email protected] , (Belgium)
  • 7 Department of Human Structure and Repair, University of Ghent Faculty of Medicine, Ghent 9000, Belgium. Electronic address: [email protected] , (Belgium)
  • 8 Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent 9000, Belgium. Electronic address: [email protected] , (Belgium)
  • 9 Department of Radiology, Ghent University Hospital, Ghent 9000, Belgium. Electronic address: [email protected] , (Belgium)
  • 10 Department of Pathology, Ghent University Hospital, Ghent 9000, Belgium. Electronic address: [email protected] , (Belgium)
  • 11 Department of Pathology, Ghent University Hospital, Ghent 9000, Belgium. Electronic address: [email protected] , (Belgium)
Type
Published Article
Journal
Clinics and research in hepatology and gastroenterology
Publication Date
May 01, 2021
Volume
45
Issue
3
Pages
101478–101478
Identifiers
DOI: 10.1016/j.clinre.2020.06.004
PMID: 32620388
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Preoperative imaging and histopathology, immunohistochemistry and molecular analysis after resection of 2 hepatocellular adenomas (HCAs) (20 and 2cm) in a 53-year-old female patient were performed. On imaging, the large lesion resembled a myxoid HCA, while the small lesion resembled a more conventional HCA with a small myxoid/fluid area. On microscopy, the large lesion showed cords and nests of hepatocytes embedded in abundant myxoid matrix, while the small lesion resembled a conventional HCA with small foci of myxoid change and serosities; both consistent with a myxoid HCA. Immunophenotyping and molecular subtyping excluded inflammatory HCA, CTNNB1 mutated HCA and sonic hedgehog HCA, and was consistent with HNF1A mutated HCA. The myxoid change as well as the serosities may allow imaging diagnosis of myxoid HCA. As fluid vacuoles can also be present in ASS1+HCA, sonic hedgehog HCA has to be considered in the differential diagnosis. Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

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