Recent studies showed that inflammation is a critical cause for initiation and/or development of many cancers. In prostate cancer (PC), the inflammatory cells usually populate an immune-competent organ. This inflammatory organ can be involved in the initiation and progression of PC. Here, we mainly focus on the role of inflammation in the PC and progression of castration-resistant PC (CRPC). Moreover, we summarize the roles of inflammation factors (such as chemokines and cytokines) in PC and CRPC. Taken together, this review gives an insight into therapy for PC and CRPC through anti-inflammation.