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Myothermal economy of rat myocardium, chronic adaptation versus acute inotropism.

Authors
  • Holubarsch, C
  • Hasenfuss, G
  • Blanchard, E
  • Alpert, N R
  • Mulieri, L A
  • Just, H
Type
Published Article
Journal
Basic research in cardiology
Publication Date
Jan 01, 1986
Volume
81 Suppl 1
Pages
95–102
Identifiers
PMID: 3790048
Source
Medline
License
Unknown

Abstract

By means of rapid planar Hill type antimony-bismuth thermophiles the initial heat liberated by papillary muscles was measured synchronously with developed tension for control (C), pressure-overload (GOP), and hypothyrotic (PTU) rat myocardium (chronic experiments) and after application of 10(-6) M isoproterenol or 200 10(-6) M UDCG-115. Economy of force production was analyzed by the ratio of initial heat versus developed tension-time integral. This ratio was found to be reduced by 34% in GOP and by 43% in PTU myocardium (P less than 0.01, respectively) indicating increased economy of force production. In contrast, isoproterenol increased initial heat versus tension-time integral by 70% (P less than 0.01) indicating reduced economy of force production. No change in this ratio was found for UDCG-115. The presented data indicates that long and short term modulation of myocardial energetic costs of force generation is possible. The basic mechanisms for these myocardial alterations are discussed.

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