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Myosin 1g regulates cytoskeleton plasticity, cell migration, exocytosis, and endocytosis in B lymphocytes.

Authors
  • Maravillas-Montero, José L1
  • López-Ortega, Orestes
  • Patiño-López, Genaro
  • Santos-Argumedo, Leopoldo
  • 1 Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México.
Type
Published Article
Journal
European Journal of Immunology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Mar 01, 2014
Volume
44
Issue
3
Pages
877–886
Identifiers
DOI: 10.1002/eji.201343873
PMID: 24310084
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Myosin 1g (Myo1g) is a hematopoietic-specific myosin expressed mainly by lymphocytes. Here, we report the localization of Myo1g in B-cell membrane compartments such as lipid rafts, microvilli, and membrane extensions formed during spreading. By using Myo1g-deficient mouse B cells, we detected abnormalities in the adhesion ability and chemokine-induced directed migration of these lymphocytes. We also assessed a role for Myo1g in phagocytosis and exocytosis processes, as these were also irregular in Myo1g-deficient B cells. Taken together, our results show that Myo1g acts as a main regulator of different membrane/cytoskeleton-dependent processes in B lymphocytes. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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