Affordable Access

Myocardial protection by perfluorochemical infusion during transient ischemia produced by balloon coronary occlusion.

Authors
  • Virmani, R1
  • Kolodgie, F D
  • Osmialowski, A
  • Zimmerman, P
  • Mergner, W
  • Forman, M B
  • 1 Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306.
Type
Published Article
Journal
American Heart Journal
Publisher
Elsevier
Publication Date
Aug 01, 1988
Volume
116
Issue
2 Pt 1
Pages
421–431
Identifiers
PMID: 2969667
Source
Medline
License
Unknown

Abstract

To assess the efficacy of the perfluorochemical Fluosol-DA 20% for myocardial protection during repeated periods of balloon occlusion of the left circumflex coronary artery, 25 anesthetized dogs were randomized to receive either oxygenated perfluorochemical, (Fluosol-DA [F]; n = 10) or oxygenated Ringer's lactate (R; n = 6), at the rate of 30 ml/min, during inflation of the balloon. A control group (C; n = 9) received no infusion. A total of eight inflations were performed, each lasting 90 seconds, followed by an equivalent deflation time. Hemodynamics, ECGs, regional myocardial function, and biochemical parameters were studied. Significant differences were noted in ST segment elevation at 90 seconds of inflation in the F (1.5 mm +/- 0.6), C (3.7 mm +/- 0.75), and R (2.9 mm +/- 0.75) groups (F vs C or R p less than 0.05). This was associated with significant improvement in radial shortening in the jeopardized zone at 45 seconds into occlusion in the F group compared to the C and R groups (F = 21.1% +/- 5.1 vs C = 3.5% +/- 4.5 or R = 1.1% +/- 3.2; p less than 0.05). Results of electron microscopy showed reversible changes of ischemia within the mitochondria, and these were most marked in the C and R groups compared to the F group. Endothelial swelling was mild and was present only focally in the R and C groups. Thus perfluorochemicals may enhance the safety and efficacy of balloon angioplasty.

Report this publication

Statistics

Seen <100 times