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Myeloid hypoxia-inducible factors in inflammatory diseases.

Authors
  • 1
  • 1 Servicio de Inmunología, Hospital Universitario de La Princesa, Madrid, Spain. [email protected] , (Spain)
Type
Published Article
Journal
Critical Reviews in Immunology
1040-8401
Publisher
Begell House Inc.
Publication Date
Volume
31
Issue
1
Pages
1–13
Identifiers
PMID: 21395507
Source
Medline
License
Unknown

Abstract

Hypoxia inducible factors (HIF1 and HIF2) have emerged as central regulators of the activity of myeloid cells at inflammatory sites where O(2) is frequently limited. Novel insights in the field have revealed that the expression of HIFs by myeloid cells is not exclusively induced by hypoxia but also in response to central inflammatory mediators independently of O(2) shortage. This has substantially elevated the biological significance of HIFs in the context of inflammatory diseases. As a consequence, the loss of HIF1 or HIF2 in myeloid cells specifically compro-mises some of the processes driven by myeloid cells, such as bactericidal activity and myeloid invasion, as well as inflammation-associated detrimental consequences.

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