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Mycoplasma bovis: Interactions with the Immune System and Failure to Generate an Effective Immune Response.

Authors
  • Maunsell, Fiona P1
  • Chase, Christopher2
  • 1 Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, PO Box 100136, Gainesville, FL 32610, USA. Electronic address: [email protected]
  • 2 Department of Veterinary and Biomedical Sciences, South Dakota State University, PO Box 2175, SAR Room 125 North Campus Drive, Brookings, SD 57007, USA.
Type
Published Article
Journal
The Veterinary clinics of North America. Food animal practice
Publication Date
Nov 01, 2019
Volume
35
Issue
3
Pages
471–483
Identifiers
DOI: 10.1016/j.cvfa.2019.08.003
PMID: 31590898
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Host responses are often ineffective at clearing Mycoplasma bovis infection and may contribute to the pathogenesis of disease. M bovis possesses a surprisingly large repertoire of strategies to evade and modulate host responses. Unopsonized M bovis impairs phagocytosis and killing by neutrophils and macrophages. Apoptosis of neutrophils and lymphocytes is enhanced, whereas it is delayed in macrophages. Both proinflammatory and antiinflammatory cytokines are stimulated during M bovis infection depending on the cell type and location, and overall systemic responses tend to have a T-helper 2 bias. M bovis reduces proliferation of T cells and, in chronic infection, causes T-cell exhaustion. Copyright © 2019 Elsevier Inc. All rights reserved.

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