Affordable Access

deepdyve-link
Publisher Website

Mycophenolate mofetil following glucocorticoid treatment in Henoch-Schönlein purpura nephritis: the role of early initiation and therapeutic drug monitoring.

Authors
  • Hackl, Agnes1
  • Becker, Jan U2
  • Körner, Lisa M3
  • Ehren, Rasmus3
  • Habbig, Sandra3
  • Nüsken, Eva3
  • Nüsken, Kai-Dietrich3
  • Ebner, Kathrin3
  • Liebau, Max C3, 4, 5
  • Müller, Carsten6
  • Pohl, Martin7
  • Weber, Lutz T3
  • 1 Pediatric Nephrology, Children's and Adolescents' Hospital, University Hospital of Cologne, Kerpener Street 62, 50937, Cologne, Germany. [email protected] , (Germany)
  • 2 Institute of Pathology, University Hospital of Cologne, Cologne, Germany. , (Germany)
  • 3 Pediatric Nephrology, Children's and Adolescents' Hospital, University Hospital of Cologne, Kerpener Street 62, 50937, Cologne, Germany. , (Germany)
  • 4 Nephrology Research Laboratory, Department II of Internal Medicine, University Hospital of Cologne, Cologne, Germany. , (Germany)
  • 5 Center for Molecular Medicine, University Hospital of Cologne, Cologne, Germany. , (Germany)
  • 6 Department of Therapeutic Drug Monitoring, Centre of Pharmacology, University Hospital of Cologne, Cologne, Germany. , (Germany)
  • 7 Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - Faculty of Medicine, University of Freiburg Germany, Freiburg, Germany. , (Germany)
Type
Published Article
Journal
Pediatric Nephrology
Publisher
Springer-Verlag
Publication Date
Apr 01, 2018
Volume
33
Issue
4
Pages
619–629
Identifiers
DOI: 10.1007/s00467-017-3846-6
PMID: 29177628
Source
Medline
Keywords
License
Unknown

Abstract

Our study demonstrates that MMF is a safe and potentially effective secondary treatment option for children with HSPN to achieve and maintain long-term remission without serious side effects. To achieve complete remission within 3 months, resolve severe inflammatory glomerular lesions, and avoid progression to chronic kidney disease, we propose timely diagnosis and early initiation of MMF with an eMPA-AUC0-12h value of 56.4 mg*h/l.

Report this publication

Statistics

Seen <100 times