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Mutations of the VCORC1 Gene of Resistance to Anticoagulants in Synanthropic Rodents in Urbanized Areas of Russia

Authors
  • Maltsev, A. N.1
  • Ryabov, S. V.2
  • Stakheev, V. V.3
  • Panasjuk, N. V.3
  • Gashev, S. N.4
  • Sorokina, N. V.4
  • Bazhenov, Y. A.5
  • Kotenkova, E. V.1
  • 1 Severtsov Institute of Problems of Ecology and Evolution, Russian Academy of Sciences, Moscow, 119071, Russia , Moscow (Russia)
  • 2 Research Institute of Disinfectology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, 117246, Russia , Moscow (Russia)
  • 3 Southern Research Center, Russian Academy of Sciences, Rostov-on-Don, 344006, Russia , Rostov-on-Don (Russia)
  • 4 University of Tyumen, Tyumen, 625003, Russia , Tyumen (Russia)
  • 5 Institute of Natural Resources, Ecology and Cryology, Siberian Branch, Russian Academy of Sciences, Chita, 672090, Russia , Chita (Russia)
Type
Published Article
Journal
Doklady Biological Sciences
Publisher
Pleiades Publishing
Publication Date
May 01, 2021
Volume
498
Issue
1
Pages
82–84
Identifiers
DOI: 10.1134/S0012496621030029
Source
Springer Nature
Keywords
Disciplines
  • General Biology
License
Yellow

Abstract

AbstractThis is the first study to analyze the variability of two exons (the 1st and 3rd) of the VCORC1 gene in Russian populations of mice and rats, namely, 125 Mus musculus and 19 Rattus norvegicus captured in 13 settlements. Previously, it has been shown that a number of mutations in these exons in the countries of Western Europe are associated with resistance to anticoagulants in synanthropic rodents. We did not find such mutations in house mice in Russia. However, in the first exon, two previously unknown mutations were identified that could potentially have such an effect (Lys58Arg and Ser31Trp). In three districts of Moscow, Norway rats were found carrying in the third exon a previously known resistance mutation (Tyr139Ser) in the heterozygous state. The results are discussed in connection with the intensity of the use of anticoagulants in the settlements of Russia and the mutation rate of the VCORC1 gene.

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