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[Mutations of growth factor receptor Flt3 in acute myeloid leukemia: transformation of myeloid cells by Ras-dependent and Ras-independent mechanisms].

Authors
  • Müller-Tidow, C
  • Steur, C
  • Mizuki, M
  • Schwäble, J
  • Brandts, C
  • Berdel, W E
  • Serve, H
Type
Published Article
Journal
Deutsche medizinische Wochenschrift (1946)
Publication Date
Oct 18, 2002
Volume
127
Issue
42
Pages
2195–2200
Identifiers
PMID: 12397548
Source
Medline
License
Unknown

Abstract

Inhibition of Ras-dependent signaling pathways is not sufficient to abrogate the functional consequences of Flt3-mutations in myeloid cells. Therefore, therapeutic intervention by Ras-Inhibitors may not be sufficient to treat Flt3-driven disease.

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