[Mutations of growth factor receptor Flt3 in acute myeloid leukemia: transformation of myeloid cells by Ras-dependent and Ras-independent mechanisms].
- Published Article
Deutsche medizinische Wochenschrift (1946)
- Publication Date
Oct 18, 2002
Inhibition of Ras-dependent signaling pathways is not sufficient to abrogate the functional consequences of Flt3-mutations in myeloid cells. Therefore, therapeutic intervention by Ras-Inhibitors may not be sufficient to treat Flt3-driven disease.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/12397548