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Mutational patterns and novel mutations of the BRAF gene in a large cohort of Korean patients with papillary thyroid carcinoma.

Authors
  • Jung, Chan-Kwon
  • Im, So-Young
  • Kang, Yeo-Ju
  • Lee, Hyoungnam
  • Jung, Eun-Sun
  • Kang, Chang-Suk
  • Bae, Ja-Seong
  • Choi, Yeong-Jin
Type
Published Article
Journal
Thyroid
Publisher
Mary Ann Liebert
Publication Date
Aug 01, 2012
Volume
22
Issue
8
Pages
791–797
Identifiers
DOI: 10.1089/thy.2011.0123
PMID: 22471241
Source
Medline
License
Unknown

Abstract

Out of 1041 Korean patients with PTC, 0.4% had rare types of BRAF mutation and three new somatic mutations were identified. The BRAF mutation rate was quite low in PTC with follicular morphology regardless of tumor size. However, the prevalence of BRAF mutation in microcarcinoma and follicular variants of PTC is relatively high in Korea and its analysis may be clinically useful for managing the patients.

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