Affordable Access

deepdyve-link
Publisher Website

Mutation T74S in HIV-1 subtype B and C proteases resensitizes them to ritonavir and indinavir and confers fitness advantage.

Authors
  • Soares, Esmeralda A1
  • Santos, André F
  • Gonzalez, Luis M
  • Lalonde, Matthew S
  • Tebit, Denis M
  • Tanuri, Amilcar
  • Arts, Eric J
  • Soares, Marcelo A
  • 1 Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. , (Brazil)
Type
Published Article
Journal
Journal of Antimicrobial Chemotherapy
Publisher
Oxford University Press
Publication Date
Nov 01, 2009
Volume
64
Issue
5
Pages
938–944
Identifiers
DOI: 10.1093/jac/dkp315
PMID: 19710076
Source
Medline
License
Unknown

Abstract

Our results suggest that T74S is not a major drug resistance mutation, but it resensitizes multiresistant viruses to certain PIs. T74S is a bona fide accessory mutation, restoring fitness of multidrug-resistant viruses in both subtypes B and C. T74S should be further studied in clinical settings and considered in drug resistance interpretation algorithms.

Report this publication

Statistics

Seen <100 times