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Mutation profile of over 4500 SARS-CoV-2 isolations reveals prevalent cytosine-to-uridine deamination on viral RNAs.

Authors
  • Li, Yue1
  • Yang, Xinai1
  • Wang, Na1
  • Wang, Haiyan1
  • Yin, Bin1
  • Yang, Xiaoping1
  • Jiang, Wenqing1
  • 1 Department of Respiratory Diseases, Qingdao Haici Hospital, Qingdao, Shandong, China. , (China)
Type
Published Article
Journal
Future Microbiology
Publisher
Future Medicine
Publication Date
Sep 01, 2020
Volume
15
Pages
1343–1352
Identifiers
DOI: 10.2217/fmb-2020-0149
PMID: 33085541
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Aim: The inference of coronavirus evolution is largely based on mutations in SARS-CoV-2 genome. Misinterpretation of these mutations would mislead people about the evolution of SARS-CoV-2. Materials & methods: With 4521 lines of SARS-CoV-2, we obtained 3169 unique point mutation sites. We counted the numbers and calculated the minor allele frequency (MAF) of each mutation type. Results: Nearly half of the point mutations are C-T mismatches and 20% are A-G mismatches. The MAF of C-T and A-G mismatches is significantly higher than MAF of other mutation types. Conclusion: The excessive C-T mismatches do not resemble the random mutation profile. They are likely to be caused by the cytosine-to-uridine deamination system in hosts.

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